Calm Gentle Retinal Serum reduces inflammation and sensitivity while rebuilding your skin’s outer layer. It tackles all signs of aging from fine lines and wrinkles, to sagging skin and weak barrier functions. It also increases the supply of nutrients and moisture.

The Osmosis Calm serum leaves skin looking and feeling healthier and more radiant. It is perfect for those looking to achieve dramatic age reversal.


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This gentle retinal serum rejuvenates deep into the skin’s surface, while calming sensitive skin. Osmosis Calm Gentle Retinal Serum contains 7 liposomal antioxidants to restore the lipid barrier and protect the skin from damaging free radicals. Additionally, soothing botanicals help reduce inflammation to restore skin balance.

The Osmosis Calm serum also includes 7 non-irritating collagen and elastin stimulators for anti-aging benefits. A loss of collagen and elastin leads to sagging skin thats lacking in volume. Osmosis Calm actively works to stimulate these skin factors leading to a reduction in fine lines and wrinkles. Furthermore, skin will appear fuller and more youthful.

  • Reduces inflammation and sensitivity
  • Tackles all signs of aging
  • Increases nutrient supply and moisture
  • Dramatic age reversal
  • Suitable for sensitive skin

Calm Gentle Retinal Serum from Osmosis Skincare UK is a vitamin A serum that is designed for all skin types, especially aging skin. It rebuilds your skin’s outer dermis while reducing skin inflammation.

The Osmosis Calm serum also increases the supply of nutrients, as well as moisture. Additional vitamin A conditions your complexion to encourage quicker skin rejuvenation.

Osmosis skincare focuses on nourishing your skin from the inside out. Furthermore, Osmosis UK products directly target the cause of your skin concerns to deliver permanent improvements.

Using scientifically researched actives, Osmosis skincare ingredients help to uniquely restore and strengthen skin of any age. Resultantly, their transparent formulations and scientific approach has led Osmosis UK to becoming one of the most trusted global skincare brands.

Specialising in anti-aging, as well as rosacea, and blemish-prone skin, the results of Osmosis UK are unmatched.

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IDEAL FOR: Acne-Prone Skin, Anti-Aging, Sun Damage, Hyperpigmentation, Rosacea, Scars including Post-Acne Scars

SKIN TYPES: All skin types including Aging Skin, Mature Skin, Acne-Prone Skin, Hyperpigmentation, Rosacea, Sensitive Skin

Key ingredients:

Retinaldehyde .0375% (the least irritating form of Retinol): This stabilised form of Vitamin A slowly converts to Retinoic Acid in the skin. Retinaldehyde encourages skin cell regeneration and collagen production, conditions complexion to encourage quicker skin rejuvenation.

Lactic Acid: This acid exfoliates dead cells making skin smoother and more even.

Niacinamide, Sea Buckthorn Extract, Peptides: These help your skin maintain and retain moisture. They aid in visibly minimising enlarged pores, improving uneven skin tone, softening fine lines and wrinkles, diminishing dullness, and strengthening weakened surface.

Sea Buckthorn Extract (Hippophae Rhamnoides): It provides powerful anti-inflammatory properties, while hydrating and nourishing the skin. It protects the skin from UV radiation and has extreme healing properties mostly when it comes to burns.

Feverfew Extract (Chrysanthemum Parthenium): This delivers high antioxidant and anti‐irritant benefits. The extract can be very soothing to skin. It also has potent skin-soothing properties and can help to diminish redness.

Fulvic Acid: Fulvic acid is a very potent antioxidant and has significant effects against fine lines, wrinkles, and skin sagging. Acids do not disrupt the skin’s delicate acid mantle, whereas alkaline substances do.

Willow Herb: This extract works against acne bacteria, and is anti-inflammatory, an anti-irritant, anti-microbial, anti-viral, and cleansing. The plant also contains high levels of a tannin called oenethin B which helps regulate skin sebum – making it an ideal ingredient for restoring your skin’s natural balance.


Water (Aqua), Glycerin, Phosphatidylcholine, Pentylene Glycol, Asiaticoside, Epilobium Angustifolium Flower/Leaf/Stem Extract, Hippophae Rhamnoides (Sea Buckthorn) Extract, Chlorella Vulgaris Extract, Palmitoyl Tripeptide-38, Chrysanthemum Parthenium (Feverfew) Extract, Niacinamide, Dimethyl Sulfone, Lactic Acid, Panthenol, Pyridoxine HCl, Fulvic Acid, Prunus Serotina (Wild Cherry) Bark Extract, Retinal*, Hydroxyproline, Beta-Glucan, Rubus Chamaemorus (Cloud Berry) Seed Oil, Cinnamomum Camphora (Camphor) Bark Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil, Rosa Damascena Flower Oil, Lonicera Caprifolium (Honeysuckle ) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Hydroxypropyl Cyclodextrin, Cyclodextrin, Alcohol, Xanthan Gum, Sodium Hydroxide, Benzyl Alcohol, Potassium Sorbate.

*0.0375% Retinaldehyde

Cruelty-free, vegan, free of parabens, gluten, SLS, toxic chemicals, and artificial fragrances.


Use 1 pump once or twice daily, after cleansing and before moisturising and applying sun protection.

Osmosis serums are highly concentrated using source ingredients, and if you are new to this range we advise just a few little things.

Begin by using only 1/2 to 1 pump of serum per application for at least the first week and build up from there if needed. For optimum results, massage the serum into the skin followed by Osmosis Boost Peptide Activating Mist, or alternatively a slight addition of water on the skin.


Skincare is a ritual:
If you find the serum is struggling to be absorbed, you should take time to massage your serum into the skin thoroughly until fully absorbed. Repeat use of the Boost Peptide Activating Mist or water if needed.


Please note:
It may take a week of use before your skin becomes accustomed to the use of the rich ingredients within Osmosis serums and starts absorbing the product more effectively.

  1. Gabrielle

    This is such an all rouder of a product!

    its rare to find a Vitamin A that is not just suited for every skin type and condition but also delivers results for every type and condition!

    This retinaldehyde based treatment serum is so soothing that it defuses inflammation within minutes of application, it is incredibly hydrating for a vitamin A and it goes hand in hand with every product.

    This is 100% one of the Dermoi! top pics

  2. Claire Smith

    Has a Softer form of vitamin a known as retinaldhyde over retinol which doesn’t cause peeeling tightness redness of flaking. There is also an ingredient in here that is anti bacterial, anti irritant and anti inflammatory.great for sensitive skin as it protects the skin’s natural barrier.

  3. Fay

    I am not a specialist in cosmetics but I can feel the clinical changes of the products in my skin.
    ps: it trully goes well with every product.

  4. Caroline

    I read a lot about Osmosis and their scince behind each product and slowly became their 100% lover! This serum is number 1 is my rating as it have vitamin A and antioxidants .. – in other words, it has everything skin needs!!!!!

  5. Alina

    and in Osmosis serum it is in a form of retinaldehyde which absorbs much better without any irritation and has stronger effect on the skin health! I was looking for such product for a long time before I found it in Osmosis. Since that it’s my favourite!

  6. Katie

    And it’s a form of vitamin which doesn’t irritate skin – I really like it as regeneration of skin is happening 24/7

  7. Julia

    I am using this serum day and night, it is an absolutely amazing product!!! It absorbs immediately and even though it’s based on Vit A it is not effected by sun. Before I was using other vitamin A but my skin was too sensitive. With this serum I feel so amazing!

  8. Nuray Muzaffarova

    Doesn’t dry the skin, skin is glowing and very healthy. Skin quality improves drastically

  9. Camilla

    I love this product! After running out of the product and trying to get by without it, I finally reordered and can see and feel immediate results after 2 days! Redness immediately calmed, texture smoother and it simply feels like I have had a facial! Great product!

  10. Daria

    Have been using Osmosis products for 2 years and with visible results. I have now referred others who’ve complimented my skin and they love it also.

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